Important Ordering Information:

This is a custom peptide, and we only sell 10 units at a time due to its complex manufacturing process. Please note that it takes 3-4 weeks for manufacture and an additional 2 weeks for the product to arrive, clear inspection, and be ready for shipment to you. Payment is required in advance, and there are no refunds unless we are delayed by more than 90 working days. Thank you for your understanding and order!

FOXO4-DRI (FOXO4-D-Retro-Inverso Peptide) - Product Overview

Category: Senolytic Peptide, Anti-Aging Research

Molecular Composition: Modified peptide designed to interfere with the interaction between FOXO4 and p53.

Description:

FOXO4-DRI is a synthetic peptide designed to disrupt the interaction between the FOXO4 protein and p53, a key regulator of cell death. This disruption leads to the selective induction of apoptosis in senescent cells, which are cells that have stopped dividing and contribute to aging and age-related diseases. FOXO4-DRI is gaining attention in research focused on aging, cellular senescence, and the development of therapies aimed at extending healthspan.

Applications:

FOXO4-DRI is primarily used in scientific research exploring its potential as a senolytic agent—compounds that can selectively target and remove senescent cells. Researchers study FOXO4-DRI for its ability to promote healthy aging by reducing the burden of senescent cells, which are associated with inflammation, tissue dysfunction, and age-related diseases. The peptide is also of interest in studies investigating the molecular pathways involved in cellular senescence and the role of p53 in aging.

Mechanism of Action:

FOXO4-DRI works by interfering with the binding of the FOXO4 protein to the tumor suppressor protein p53. Under normal circumstances, this binding prevents p53 from initiating apoptosis in senescent cells. By disrupting this interaction, FOXO4-DRI allows p53 to trigger programmed cell death in these damaged or non-functional cells. This selective clearance of senescent cells is believed to reduce inflammation and improve tissue function, potentially slowing the aging process and alleviating age-related pathologies.

Research Implications:

Research into FOXO4-DRI holds promise for advancing our understanding of aging and developing interventions to combat age-related diseases. Studies often focus on its potential to improve lifespan and healthspan by reducing the accumulation of senescent cells in tissues. The peptide is also explored for its broader implications in regenerative medicine, where clearing senescent cells may enhance tissue repair and regeneration. Additionally, FOXO4-DRI is being studied in the context of cancer research, given its role in regulating apoptosis and cellular senescence.

Storage and Handling:

    •    Store at -20°C or lower to maintain stability.

    •    Reconstitute with sterile water (NOT BAC) or an appropriate buffer prior to use.

    •    Handle according to standard laboratory safety procedures, and ensure proper disposal after use.

Note: This product is intended for research and laboratory use only. It is not intended for human or veterinary applications. All handling and usage should follow established laboratory protocols.