IGF-DES (Insulin-like Growth Factor DES) - Product Overview

Category: Peptide Hormone, Growth Factor

Molecular Composition: A truncated variant of IGF-1 with a deletion of the first three amino acids at the N-terminus.

Description:

IGF-DES is a highly potent variant of Insulin-like Growth Factor 1 (IGF-1) that has been modified by the removal of the first three amino acids at the N-terminus. This alteration significantly increases its biological activity, particularly in local tissues. IGF-DES has a much lower binding affinity for IGF-binding proteins, allowing it to exert more direct and potent effects on muscle growth, tissue repair, and cellular proliferation. It is a focus of research in muscle biology, growth factor signaling, and regenerative medicine.

Applications:

IGF-DES is commonly used in scientific research to investigate its powerful anabolic effects on muscle tissue, its role in promoting cellular growth, and its potential applications in tissue repair and regeneration. Researchers explore its ability to enhance muscle hypertrophy, stimulate local tissue growth, and improve recovery from injuries. IGF-DES is also of interest in studies related to metabolic regulation and growth factor signaling pathways.

Mechanism of Action:

IGF-DES binds to the IGF-1 receptor on the surface of cells, initiating intracellular signaling pathways that promote cell growth and proliferation. Due to its reduced binding affinity for IGF-binding proteins, IGF-DES can act more freely in local environments, such as muscle tissue, where it rapidly induces anabolic effects. This makes it particularly effective in stimulating localized muscle growth and tissue repair, offering potential benefits in therapeutic contexts where enhanced regeneration is desired.

Research Implications:

Research on IGF-DES has important implications for understanding muscle growth, tissue repair mechanisms, and the development of therapies for conditions involving muscle wasting or injury. Studies often focus on its potential to accelerate muscle regeneration, enhance tissue recovery, and improve outcomes in regenerative medicine. IGF-DES is also explored for its role in cellular signaling and its potential to modulate metabolic processes.

Storage and Handling:

    •    Store at -20°C or lower to maintain peptide stability.

    •    Reconstitute with BAC (Bacteriostatic) water or a suitable buffer prior to use in experiments.

    •    Handle according to standard laboratory safety protocols, ensuring proper disposal after use.

Note: This product is intended for research and laboratory use only. It is not intended for human or veterinary applications. All handling and usage should follow established laboratory guidelines.