IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) - Product Overview

Category: Peptide Hormone, Growth Factor

Molecular Composition: Modified analog of IGF-1 with a substitution of Arginine for Glutamic Acid at position 3 and an extended N-terminal peptide sequence.

Description:

IGF-1 LR3 is a synthetic analog of the naturally occurring Insulin-like Growth Factor 1 (IGF-1). The LR3 variant is engineered to have an extended half-life and enhanced potency compared to native IGF-1, due to the substitution of arginine at position 3 and the addition of a 13-amino acid extension at the N-terminus. These modifications increase its biological activity and reduce its binding affinity to IGF-binding proteins, making IGF-1 LR3 particularly effective in research applications focused on cell growth, proliferation, and differentiation.

Applications:

IGF-1 LR3 is primarily used in scientific research to study its effects on muscle growth, tissue repair, and cellular proliferation. Researchers utilize IGF-1 LR3 in experiments investigating the molecular mechanisms of growth and development, as well as its potential applications in regenerative medicine. It is also employed in studies exploring its role in metabolism, cell survival, and its influence on anabolic processes within various tissues.

Mechanism of Action:

IGF-1 LR3 exerts its effects by binding to the IGF-1 receptor, which activates intracellular signaling pathways that promote cell growth and proliferation. Unlike native IGF-1, the LR3 variant has a significantly reduced binding affinity to IGF-binding proteins, allowing it to remain active in the body for a longer duration and enhancing its interaction with the IGF-1 receptor. This prolonged activity leads to sustained anabolic effects, making IGF-1 LR3 a powerful tool for research in muscle hypertrophy, tissue regeneration, and other growth-related processes.

Research Implications:

The extended half-life and increased potency of IGF-1 LR3 make it an essential tool in research focused on muscle growth, tissue repair, and cellular regeneration. Studies often explore its potential applications in treating muscle-wasting conditions, improving recovery from injuries, and enhancing tissue engineering approaches. IGF-1 LR3 is also studied for its potential metabolic effects, including its influence on glucose metabolism and fat utilization, which are of interest in research on metabolic disorders.

Storage and Handling:

    •    Store at -20°C or lower for long-term stability.

    •    Reconstitute with sterile water or buffer solution appropriate to the experimental protocol.

    •    Handle according to standard laboratory safety guidelines, ensuring proper disposal after use.

Note: This product is intended for research and laboratory use only. It is not intended for human or veterinary applications. Use appropriate safety precautions and follow laboratory protocols when handling this product.