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MOTS-C - Product Overview

Category: Mitochondrial-Derived Peptide, Metabolic Modulator

Molecular Composition: 16-amino acid peptide encoded by the mitochondrial 12S rRNA gene.

Description:

MOTS-C is a mitochondrial-derived peptide (MDP) known for its role in regulating metabolic functions. It is a small, naturally occurring peptide that has been shown to influence the body’s metabolic processes, particularly in the context of energy homeostasis, insulin sensitivity, and fat metabolism. MOTS-C acts as a signaling molecule that modulates cellular metabolism, making it a subject of significant interest in research focused on metabolic health, aging, and related diseases.

Applications:

MOTS-C is utilized in scientific research to explore its effects on metabolism, particularly in studies related to obesity, diabetes, and age-related metabolic decline. Researchers investigate how MOTS-C influences cellular energy production, glucose regulation, and fat metabolism. Its potential to improve metabolic health and combat insulin resistance makes it a valuable tool in preclinical studies aimed at developing therapies for metabolic disorders.

Mechanism of Action:

MOTS-C exerts its effects by activating the AMPK (AMP-activated protein kinase) pathway, which plays a crucial role in maintaining cellular energy balance. By stimulating AMPK, MOTS-C enhances glucose uptake, improves insulin sensitivity, and promotes fatty acid oxidation. This leads to increased energy expenditure and improved metabolic function. The peptide’s ability to cross the mitochondrial membrane and act within the cell nucleus adds to its unique mechanism of action, positioning it as a key player in metabolic regulation.

Research Implications:

Research on MOTS-C has significant implications for understanding the mechanisms underlying metabolic diseases and aging. Studies often focus on its potential to improve metabolic health, prevent insulin resistance, and support weight management. MOTS-C is also explored for its anti-aging properties, given its role in modulating mitochondrial function and cellular energy metabolism. The peptide’s effects on metabolism may lead to the development of novel interventions for metabolic disorders and age-related conditions.

Storage and Handling:

    •    Store at -20°C or lower for long-term preservation.

    •    Reconstitute with sterile water or appropriate buffer for experimental use.

    •    Handle with standard laboratory safety protocols, ensuring proper disposal after use.

Note: This product is intended for research and laboratory use only. It is not intended for human or veterinary applications. Proper laboratory procedures should be followed when handling this product.