Orexin B, a neuropeptide, plays a fundamental role in regulating wakefulness and promoting alertness. It influences the sleep-wake cycle by binding to specific receptors in the brain, encouraging heightened arousal and attention. As a promising tool in sleep disorder research, Orexin B demonstrates potential in managing conditions like narcolepsy and promoting vigilance. This peptide's unique properties make it a significant target for understanding sleep patterns and developing treatments for various sleep-related disorders. Its impact on the central nervous system positions Orexin B as a key element in the exploration of sleep and wake mechanisms, offering potential insights for therapeutic advancements in sleep disorders and related fields.