PT-141 (Bremelanotide) - Product Overview

Category: Melanocortin Receptor Agonist

Molecular Composition: Cyclic heptapeptide derivative of alpha-MSH (Melanocyte-Stimulating Hormone).

Description:

PT-141, also known as Bremelanotide, is a synthetic peptide that functions as a melanocortin receptor agonist. It is derived from the alpha-Melanocyte-Stimulating Hormone (alpha-MSH) and is primarily known for its influence on the melanocortin receptors in the central nervous system. PT-141 has been studied for its potential effects on various physiological processes, particularly those related to arousal and vasodilation.

Applications:

PT-141 is widely used in scientific research focusing on neurobiology, pharmacology, and vascular biology. Its ability to activate melanocortin receptors, particularly MC1R and MC4R, makes it a valuable tool in studies investigating the regulation of sexual function, energy homeostasis, and immune responses. Researchers also explore its potential in modulating cardiovascular function and its role in neuroprotective mechanisms.

Mechanism of Action:

PT-141 acts primarily by binding to and activating melanocortin receptors, especially MC4R, which are involved in a variety of physiological responses. Unlike other melanocortin peptides that primarily affect skin pigmentation, PT-141 has been shown to influence sexual arousal and behavior by affecting the central nervous system. Its mechanism involves the stimulation of pathways that lead to increased blood flow and enhanced neural activity related to arousal and desire.

Research Implications:

Research on PT-141 has broad implications in the fields of sexual medicine, neurobiology, and cardiovascular health. Studies often focus on its role in influencing sexual behavior, its potential therapeutic applications for sexual dysfunction, and its effects on vascular tone and blood pressure regulation. PT-141 is also studied for its neuroprotective properties, given its impact on melanocortin receptors in the brain.

Storage and Handling:

    •    Store at -20°C or lower for long-term stability.

    •    Reconstitute with BAC or. deionized water appropriate to the experimental protocol.

    •    Handle with care and dispose of according to laboratory safety guidelines.

Note: This product is intended for research and laboratory use only. It is not intended for human or veterinary applications. Appropriate safety precautions should be followed, and it should be handled in accordance with standard laboratory protocols.