≥98% HPLC PURITY

Dihexa

10mg / 10 VIALS

MINDTEK · RESEARCH USE ONLY

RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

Dihexa

Dihexa (PNB-0408)

HGF/MET receptor-activating nootropic. Synaptogenesis and hippocampal neuroplasticity research at picomolar concentrations.

MW: 490.6 Da CAS: 1401708-83-5 Per Vial: 10mg Kit: 10 Vials

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Mechanism of Action

Dihexa (PNB-0408) is a small-molecule HGF receptor (MET) activator. At picomolar concentrations, promotes synaptogenesis and hippocampal LTP. Mechanism: indirect HGF potentiation via angiotensin IV receptor (AT4) binding, activating MET downstream signalling for neurotrophic effects.

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AT4/MET Receptor Activation

Primary receptor engagement pathway confirmed in vitro and in vivo.

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Hippocampal Synaptogenesis

Downstream signalling cascade activating repair and regenerative gene expression.

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Long-Term Potentiation (LTP)

Tertiary effect pathway documented across multiple independent research groups.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

McCoy AT et al. (2013) J Pharmacol Exp Ther 347(2)DATA

Dihexa demonstrated cognitive rescue in aged rats at 7 log units more potent than BDNF in Morris Water Maze (DATA).

Benoist CC et al. (2014) J Pharmacol Exp Ther 351(3)DATA

Dihexa facilitated new spine synapse formation and restored synaptic density in scopolamine-induced amnesia models (DATA).

Wright JW et al. (2015) Prog Neurobiol 125DATA

HGF/MET-AT4 receptor system reviewed: Dihexa confirmed as most potent synaptogenic compound tested (DATA).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%

Bacterial Endotoxins≤5 EU/mg

Water Content (Karl Fischer)≤8.0%

Peptide Content≥80%

StandardUSP/EP

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Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution

Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.

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Storage

Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.

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Administration

SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is Dihexa?

Dihexa (PNB-0408) is a synthetic angiotensin IV analogue and indirect HGF/MET activator. Research: picomolar-potency synaptogenesis and cognitive rescue in aged/amnestic animal models. Research use only.

How potent is Dihexa vs. BDNF?

In Morris Water Maze, Dihexa demonstrated efficacy at 7 logarithmic units lower concentration than BDNF — ~10 million-fold greater molar potency (McCoy et al., 2013, DATA).

Is Dihexa available for order?

Availability subject to stock and regulatory confirmation. Contact us directly for current availability and research pricing.

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