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≥98% HPLC PURITY
MOTS-c
10mg / 10 VIALS
MINDTEK · RESEARCH USE ONLY
RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

MOTS-c

Mitochondrial-Derived Peptide

16-amino-acid mitochondrial-derived peptide encoded by the 12S rRNA region of mtDNA. Activates AMPK signalling to regulate metabolic homeostasis and insulin sensitivity in research models.

MW: 2174.6 Da CAS: 1627580-64-6 Per Vial: 10mg Kit: 10 Vials
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1 Vial $95Order
3 Vials Save 17%$89 eaOrder
5 Vials Save 12%$79 eaOrder
10 Vials Best Value$69 eaOrder

Mechanism of Action

MOTS-c is encoded within the mitochondrial 12S rRNA and translocates to the nucleus under metabolic stress. It activates the AMPK pathway, enhancing glucose utilisation and fatty-acid oxidation, and modulates the folate-methionine cycle in research models.

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AMPK Activation
Master metabolic switch engaged under energetic stress.
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Glucose Regulation
Enhanced glucose uptake and insulin sensitivity in research models.
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Nuclear Translocation
Stress-dependent nuclear signalling documented in vitro and in vivo.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

Lee C et al. (2015) Cell Metab 21(3)DATA
Identified MOTS-c as a mitochondrial-derived peptide regulating insulin sensitivity and metabolic homeostasis via AMPK (DATA).
Reynolds JC et al. (2021) Nat Commun 12DATA
Characterised MOTS-c as an exercise-induced regulator of metabolic adaptation in research models (DATA).
Mechanistic synthesis · AMPK axisDATA
AMPK-mediated metabolic regulation is the rationale for research interest in this compound (INFERENCE).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%
Bacterial Endotoxins≤5 EU/mg
Water Content (Karl Fischer)≤8.0%
Peptide Content≥80%
StandardUSP/EP

Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution
Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.
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Storage
Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.
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Administration
SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MRWQEMGYIFYPRKLR) encoded by the mitochondrial 12S rRNA. Research applications: metabolic, AMPK-pathway, and mitochondrial research. Research use only.
How is Mindtek MOTS-c produced?
Synthesised via solid-phase peptide synthesis (SPPS). Each batch: HPLC purity verification (≥99.3%), mass spectrometry identity, endotoxin testing prior to release.
Storage requirements?
Store solution-phase MOTS-c at -20°C. Post-reconstitution with sterile BAC water: 2–8°C, use within 28 days. Avoid repeated freeze-thaw cycles.

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Mindtek ships solution-phase, independently verified research compounds to qualified researchers globally. First in Southeast Asia.

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