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≥98% HPLC PURITY
HGH Frag 176-191
5mg / 10 VIALS
MINDTEK · RESEARCH USE ONLY
RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

HGH Frag 176-191

C-Terminal Lipolytic Fragment

C-terminal fragment of human growth hormone (residues 176-191). Isolates the fat-mobilising activity of GH, stimulating lipolysis via beta3-adrenergic pathways without the anabolic or diabetogenic effects of the full hormone in research models.

MW: 1817.1 Da CAS: 66004-57-7 Per Vial: 5mg Kit: 10 Vials
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3 Vials Save 8%$55 eaOrder
5 Vials Save 18%$49 eaOrder
10 Vials Best Value$40 eaOrder

Mechanism of Action

HGH Fragment 176-191 corresponds to the C-terminal lipolytic domain of human growth hormone. It stimulates lipolysis and inhibits lipogenesis through beta3-adrenergic-receptor-linked cAMP/PKA signalling in adipocytes, while lacking the IGF-1, glucose, and growth effects of intact hGH in research models.

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Lipolytic C-Terminus
Isolates the fat-mobilising 176-191 domain of growth hormone.
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Beta3-AR / cAMP Signalling
cAMP-PKA activation of hormone-sensitive lipase in adipocytes.
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No Anabolic / Glycaemic Effect
IGF-1 and glucose handling unaffected in research models.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

Ng FM & Bornstein J (1978) Am J Physiol 234(5)DATA
Synthetic C-terminal hGH fragments retained the lipolytic activity of the intact hormone, dissociated from anabolic effects (DATA).
Heffernan MA et al. (2001) Endocrinology 142(12)DATA
The GH lipolytic fragment increased fat oxidation and reduced body weight via beta3-AR-dependent pathways in research models (DATA).
Mechanistic synthesis · beta3-AR lipolysisDATA
Pure lipolytic activity without GH-anabolic effects is the rationale for research interest (INFERENCE).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%
Bacterial Endotoxins≤5 EU/mg
Water Content (Karl Fischer)≤8.0%
Peptide Content≥80%
StandardUSP/EP

Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution
Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.
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Storage
Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.
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Administration
SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is HGH Frag 176-191?
HGH Fragment 176-191 is the C-terminal fragment of human growth hormone (hGH residues 176-191) derived from the growth-hormone C-terminus. Research applications: adipose-metabolism and lipolysis research. Research use only.
How is Mindtek HGH Frag 176-191 produced?
Synthesised via solid-phase peptide synthesis (SPPS). Each batch: HPLC purity verification (≥99.3%), mass spectrometry identity, endotoxin testing prior to release.
Storage requirements?
Store solution-phase HGH Frag 176-191 at -20°C. Post-reconstitution with sterile BAC water: 2–8°C, use within 28 days. Avoid repeated freeze-thaw cycles.

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