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≥98% HPLC PURITY
LL-37
5mg / 10 VIALS
MINDTEK · RESEARCH USE ONLY
RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

LL-37

Human Cathelicidin Peptide

37-amino-acid human cathelicidin-derived peptide (hCAP-18 C-terminus). Broad antimicrobial and immunomodulatory activity, disrupting microbial membranes and modulating host innate responses in research models.

MW: 4493.3 Da CAS: 154947-66-7 Per Vial: 5mg Kit: 10 Vials
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1 Vial $90Order
3 Vials Save 12%$79 eaOrder
5 Vials Save 17%$75 eaOrder
10 Vials Best Value$65 eaOrder

Mechanism of Action

LL-37 is the sole human cathelicidin peptide. It forms amphipathic helices that permeabilise microbial membranes and also binds host receptors (FPR2, P2X7) to modulate chemotaxis, angiogenesis, and wound-associated inflammation in research models.

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Membrane Disruption
Amphipathic helix permeabilises microbial membranes.
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FPR2 Signalling
Host-receptor engagement modulating chemotaxis.
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Immune Modulation
Angiogenesis and inflammation modulation in research models.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

Durr UHN et al. (2006) Biochim Biophys Acta 1758(9)DATA
Reviewed LL-37 structure and its membrane-disruptive antimicrobial mechanism (DATA).
Vandamme D et al. (2012) Cell Immunol 280(1)DATA
Characterised LL-37 immunomodulatory receptor interactions across research models (DATA).
Mechanistic synthesis · cathelicidin axisDATA
Dual antimicrobial and immunomodulatory action is the rationale for research interest (INFERENCE).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%
Bacterial Endotoxins≤5 EU/mg
Water Content (Karl Fischer)≤8.0%
Peptide Content≥80%
StandardUSP/EP

Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution
Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.
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Storage
Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.
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Administration
SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is LL-37?
LL-37 is a 37-amino-acid human cathelicidin peptide (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES) the human cathelicidin peptide. Research applications: antimicrobial, wound-healing, and innate-immunity studies. Research use only.
How is Mindtek LL-37 produced?
Synthesised via solid-phase peptide synthesis (SPPS). Each batch: HPLC purity verification (≥99.3%), mass spectrometry identity, endotoxin testing prior to release.
Storage requirements?
Store solution-phase LL-37 at -20°C. Post-reconstitution with sterile BAC water: 2–8°C, use within 28 days. Avoid repeated freeze-thaw cycles.

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Mindtek ships solution-phase, independently verified research compounds to qualified researchers globally. First in Southeast Asia.

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