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≥98% HPLC PURITY
TB-500
5mg / 10 VIALS
MINDTEK · RESEARCH USE ONLY
RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

TB-500

Thymosin Beta-4 (TB-500)

43-amino-acid actin-sequestering peptide. Neurorestorative and angiogenic properties across TBI and musculoskeletal models.

MW: 4963.5 Da CAS: 77591-33-4 Per Vial: 5mg Kit: 10 Vials
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1 Vial $60Order
3 Vials Save 8%$55 eaOrder
5 Vials Save 18%$49 eaOrder
10 Vials Best Value$40 eaOrder

Mechanism of Action

TB-500 sequesters G-actin via its LKKTET motif, promoting cell migration and proliferation. Neurorestorative activity operates via neurogenesis and synaptogenesis amplification post-TBI. Angiogenic mechanism: promotes new vessel formation, improving tissue oxygenation in ischaemic injury models.

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G-Actin Sequestration (LKKTET)
Primary receptor engagement pathway confirmed in vitro and in vivo.
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Neurogenesis & Synaptogenesis
Downstream signalling cascade activating repair and regenerative gene expression.
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Post-Ischaemic Angiogenesis
Tertiary effect pathway documented across multiple independent research groups.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

Bock-Marquette I et al. (2004) Nature 432DATA
Thymosin β4 activated ILK, promoted cardiac cell migration and survival post-MI in rodent models (DATA).
Xiong Y et al. (2020) Neural Regen Res 15(2)DATA
TB-500 improved neurological function scores and reduced infarct volume vs. vehicle at 24-hr delayed treatment in TBI models (DATA).
Goldstein AL & Kleinman HK (2015) Ann N Y Acad Sci 1348DATA
TB-500 mechanism reviewed: hair follicle regeneration, wound healing, and cardioprotective endpoints documented (DATA).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%
Bacterial Endotoxins≤5 EU/mg
Water Content (Karl Fischer)≤8.0%
Peptide Content≥80%
StandardUSP/EP

Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution
Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.
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Storage
Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.
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Administration
SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is TB-500?
TB-500 (Thymosin Beta-4) is a 43-amino-acid peptide sequestring G-actin via its LKKTET sequence. Research demonstrates neurorestorative, angiogenic, and musculoskeletal repair properties. Research use only.
Purity of Mindtek TB-500?
Batch-verified ≥98.82% purity by HPLC. Full CoA including mass spectrometry and endotoxin data available on request.
How does TB-500 differ from BPC-157?
TB-500 acts via G-actin sequestration/LKKTET-driven cell migration; BPC-157 targets FAK-paxillin and GHR upregulation. Research protocols frequently combine both for complementary tissue repair.

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Mindtek ships solution-phase, independently verified research compounds to qualified researchers globally. First in Southeast Asia.

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