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≥98% HPLC PURITY
KPV
5mg / 10 VIALS
MINDTEK · RESEARCH USE ONLY
RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

KPV

Alpha-MSH C-Terminal Tripeptide

C-terminal tripeptide of alpha-melanocyte-stimulating hormone (Lys-Pro-Val). Carries the anti-inflammatory activity of alpha-MSH without pigmentary effects in research models.

MW: 342.43 Da CAS: 67727-97-3 Per Vial: 5mg Kit: 10 Vials
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1 Vial $75Order
3 Vials Save 8%$69 eaOrder
5 Vials Save 21%$59 eaOrder
10 Vials Best Value$55 eaOrder

Mechanism of Action

KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-MSH. It inhibits NF-kB and MAPK inflammatory signalling and is taken up by the PepT1 transporter in enterocytes, reducing pro-inflammatory cytokine output in research models, without melanocortin-receptor pigmentary effects.

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NF-kB Inhibition
Suppresses pro-inflammatory transcriptional signalling.
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PepT1 Transport
Enterocyte uptake relevant to gut-inflammation models.
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Non-Pigmentary Action
Anti-inflammatory activity without melanocortin pigment effects.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

Luger TA & Brzoska T (2007) Ann Rheum Dis 66DATA
alpha-MSH-derived peptides including KPV exert anti-inflammatory effects across research models (DATA).
Dalmasso G et al. (2008) Gastroenterology 134(1)DATA
KPV reduced intestinal inflammation via PepT1-mediated uptake in colitis research models (DATA).
Mechanistic synthesis · anti-inflammatory axisDATA
Cytokine suppression without pigmentary effect is the rationale for research interest (INFERENCE).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%
Bacterial Endotoxins≤5 EU/mg
Water Content (Karl Fischer)≤8.0%
Peptide Content≥80%
StandardUSP/EP

Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution
Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.
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Storage
Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.
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Administration
SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is KPV?
KPV is the C-terminal tripeptide of alpha-MSH (Lys-Pro-Val) the C-terminal fragment of alpha-MSH. Research applications: inflammation, gut-integrity, and immune-modulation studies. Research use only.
How is Mindtek KPV produced?
Synthesised via solid-phase peptide synthesis (SPPS). Each batch: HPLC purity verification (≥99.3%), mass spectrometry identity, endotoxin testing prior to release.
Storage requirements?
Store solution-phase KPV at -20°C. Post-reconstitution with sterile BAC water: 2–8°C, use within 28 days. Avoid repeated freeze-thaw cycles.

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Mindtek ships solution-phase, independently verified research compounds to qualified researchers globally. First in Southeast Asia.

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