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≥98% HPLC PURITY
Humanin
10mg / 10 VIALS
MINDTEK · RESEARCH USE ONLY
RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

Humanin

Mitochondrial-Derived Cytoprotective Peptide

24-amino-acid mitochondrial-derived peptide encoded within the 16S rRNA region. Cytoprotective and metabolic signalling via a trimeric cell-surface receptor in research models.

MW: 2687.1 Da CAS: 330936-69-1 Per Vial: 10mg Kit: 10 Vials
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1 Vial $95Order
3 Vials Save 11%$85 eaOrder
5 Vials Save 16%$80 eaOrder
10 Vials Best Value$75 eaOrder

Mechanism of Action

Humanin is a mitochondrial-derived peptide that signals through a heterotrimeric receptor (CNTFR / WSX-1 / gp130) and antagonises pro-apoptotic Bax/BID activity. It activates STAT3 signalling and improves insulin sensitivity and cytoprotection in research models.

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Anti-Apoptotic Signalling
Antagonises Bax/BID pro-apoptotic activity.
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gp130 Receptor Complex
Signals via CNTFR/WSX-1/gp130 and STAT3.
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Metabolic Protection
Improves insulin sensitivity and cytoprotection in research models.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

Hashimoto Y et al. (2001) Proc Natl Acad Sci 98(11)DATA
Identified humanin as a peptide protecting neurons from Alzheimer-related toxicity in research models (DATA).
Muzumdar RH et al. (2009) PLoS One 4(7)DATA
Humanin improved insulin sensitivity and metabolic parameters in research models (DATA).
Mechanistic synthesis · MDP axisDATA
Cytoprotective mitochondrial-derived signalling is the rationale for research interest (INFERENCE).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%
Bacterial Endotoxins≤5 EU/mg
Water Content (Karl Fischer)≤8.0%
Peptide Content≥80%
StandardUSP/EP

Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution
Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.
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Storage
Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.
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Administration
SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is Humanin?
Humanin is a 24-amino-acid mitochondrial-derived peptide (MAPRGFSCLLLLTSEIDLPVKRRA) encoded within the mitochondrial 16S rRNA. Research applications: cytoprotection, metabolic, and neuroprotection studies. Research use only.
How is Mindtek Humanin produced?
Synthesised via solid-phase peptide synthesis (SPPS). Each batch: HPLC purity verification (≥99.3%), mass spectrometry identity, endotoxin testing prior to release.
Storage requirements?
Store solution-phase Humanin at -20°C. Post-reconstitution with sterile BAC water: 2–8°C, use within 28 days. Avoid repeated freeze-thaw cycles.

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Mindtek ships solution-phase, independently verified research compounds to qualified researchers globally. First in Southeast Asia.

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