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≥98% HPLC PURITY
ARA-290
16mg / 10 VIALS
MINDTEK · RESEARCH USE ONLY
RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

ARA-290

Innate Repair Receptor Peptide

11-amino-acid peptide derived from the erythropoietin helix-B domain (cibinetide). Activates the innate repair receptor (EPOR/CD131) for tissue protection without erythropoietic effects in research models.

MW: 1257.4 Da CAS: 1208243-50-8 Per Vial: 16mg Kit: 10 Vials
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1 Vial $90Order
3 Vials Save 11%$85 eaOrder
5 Vials Save 10%$80 eaOrder
10 Vials Best Value$70 eaOrder

Mechanism of Action

ARA-290 (cibinetide) mimics the helix-B surface of erythropoietin and selectively activates the innate repair receptor, a heterocomplex of EPOR and the beta-common receptor (CD131). This drives anti-inflammatory and tissue-protective signalling without stimulating erythropoiesis in research models.

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Innate Repair Receptor
Selective EPOR/CD131 heterocomplex activation.
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Non-Erythropoietic
Tissue protection without raising red-cell mass.
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Tissue Protection
Anti-inflammatory and repair signalling in research models.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

Brines M et al. (2008) Proc Natl Acad Sci 105(31)DATA
Defined a nonerythropoietic tissue-protective EPO derivative acting via the innate repair receptor (DATA).
Brines M et al. (2015) Mol Med 20(1)DATA
Cibinetide (ARA-290) reduced neuropathic symptoms via innate-repair-receptor signalling in research models (DATA).
Mechanistic synthesis · innate repair receptorDATA
Tissue protection dissociated from erythropoiesis is the rationale for research interest (INFERENCE).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%
Bacterial Endotoxins≤5 EU/mg
Water Content (Karl Fischer)≤8.0%
Peptide Content≥80%
StandardUSP/EP

Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution
Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.
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Storage
Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.
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Administration
SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is ARA-290?
ARA-290 is an 11-amino-acid EPO-derived peptide (pyroGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser) derived from the erythropoietin helix-B domain. Research applications: tissue-protection, neuropathy, and inflammation studies. Research use only.
How is Mindtek ARA-290 produced?
Synthesised via solid-phase peptide synthesis (SPPS). Each batch: HPLC purity verification (≥99.3%), mass spectrometry identity, endotoxin testing prior to release.
Storage requirements?
Store solution-phase ARA-290 at -20°C. Post-reconstitution with sterile BAC water: 2–8°C, use within 28 days. Avoid repeated freeze-thaw cycles.

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