RESEARCH USE ONLY COA VERIFIED SOLUTION PHASE

NA-Semax

NA-Semax (N-Acetyl Semax)

N-acetylated ACTH 4–10 analogue. BDNF upregulation, D1/D3 receptor modulation, and neuroinflammation suppression.

MW: 813.96 Da CAS: 80714-61-0 Per Vial: 30mg Kit: 10 Vials

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Mechanism of Action

NA-Semax elevates BDNF and NGF in hippocampus and cortex, driving neuroplasticity and neuroprotection. D1/D3 dopaminergic receptor modulation underpins attention/executive function research models. Anti-inflammatory via IL-1β and TNF-α suppression in CNS injury models.

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BDNF/NGF Upregulation

Primary receptor engagement pathway confirmed in vitro and in vivo.

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D1/D3 Dopaminergic Modulation

Downstream signalling cascade activating repair and regenerative gene expression.

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Neuroinflammation Suppression

Tertiary effect pathway documented across multiple independent research groups.

Research Evidence

DATA = directly reported in cited study · INFERENCE = derived · SPECULATION = hypothesis

Dolotov OV et al. (2006) J Mol Neurosci 28(2)DATA

Semax significantly upregulated BDNF in rat hippocampus vs. controls; neuroprotective effects confirmed in ischaemic stroke model (DATA).

Shadrina MI et al. (2010) Mol Biol 44(2)DATA

Semax activated 270+ genes linked to synaptic plasticity, neurogenesis, and neuroprotection in rodent cortex at 24h (DATA).

Maleeva EE et al. (1999) Vestn Ross Akad Med NaukDATA

Semax clinical trial: improved attention and memory in ischaemic stroke patients at 12–18 mcg/kg (DATA).

Certificate of Analysis

Every Mindtek batch is independently tested before release. We were among the first peptide suppliers in Southeast Asia to implement mandatory third-party HPLC verification — a standard, not an exception.

HPLC Purity≥98.0%

Bacterial Endotoxins≤5 EU/mg

Water Content (Karl Fischer)≤8.0%

Peptide Content≥80%

StandardUSP/EP

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Research Protocol Reference

For laboratory research use only — not for human or veterinary use.

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Reconstitution

Add sterile bacteriostatic water (0.9% benzyl alcohol) slowly against the vial wall. Gently swirl — do not vortex. Allow 5 min for complete dissolution.

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Storage

Store solution-phase at -20°C. Post-reconstitution: maintain at 2–8°C, use within 28 days. Protect from light. Avoid repeated freeze-thaw cycles.

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Administration

SubQ or IM administration in standard research protocols. Insulin syringe recommended for precise dosing. Refer to published literature for compound-specific protocols.

Frequently Asked Questions

What is NA-Semax?

N-acetylated, amidated form of Semax (ACTH 4–10 analogue). N-acetylation enhances bioavailability and extends activity. Research: BDNF upregulation, cognitive enhancement, neuroprotection. Research use only.

Semax vs NA-Semax?

NA-Semax adds N-acetyl group to Met, increasing resistance to aminopeptidase degradation and extending receptor engagement duration in research models.

Dose per vial?

30mg per vial. Supplied in 10-vial kits.

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Mindtek ships solution-phase, independently verified research compounds to qualified researchers globally. First in Southeast Asia.

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